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pentobarbital will decrease the extent or effect of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can decrease panobinostat degrees by ~70% and bring on therapy failure.pentobarb

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